eting
Registered: 08/07/12 Posts: 3
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Posted 08/07/12
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#1
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At the beginning of May, Diezel, our almost 8 year old mastiff, seemed to be very wobbly, almost appearing drunk when we got home from work. By the next morning he was much worse. He was falling down, almost as if his front legs were giving out and just kept getting worse, to the point where he couldn't get up at all. He has always been very healthy so we were very concerned. After taking him to our local vet he ruled out an inner ear infection and told us he felt it was neurological so we were off to Purdue University to get more testing. After going to Purdue and having an upper MRI, nerve testing, extensive blood testing, and a spinal tap, we still aren't any closer to knowing what is wrong. They offered us no real answers other than he may have something that the MRI didn't see but they don't feel it's neurological. He started immediately on 40 mg prednisone, twice a day, and antibiotics. Within two doses he was much better and we got to bring him home days before they had thought we would. He has quite the antibiotics and we have weaned him down to 10 mg, twice a day. He started having accidents in the house and after a urine test we found out his Billy-Ruben count was high, which shows that the steroid is affecting his liver. He has been taking a medicine for that for 14 days, and has had no accidents. Three days after starting the 10 mg. dose, twice a day, he started to regress. He is slowly declining in his ability to keep his balance, is wobbly, and he seems weak. His appetite is still very good and he's drinking and using the bathroom like normal. We are so sad and confused as to what is going on. If you have any advice we would love to hear it. It is heart breaking to watch him like this and we aren't getting any answers from Purdue or our local vet.
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erikam
Registered: 01/21/12 Posts: 1,530
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Posted 08/07/12
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#2
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I am so sorry for you - They have ruled out tick born paralysis, wobblers and degenerative myelopathy - spinal/ brain tumors? Has prudue given you any idea what they think it may be ?
__________________ http://www.kyniska.com
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Tracy

Moderator
Registered: 05/30/06 Posts: 7,593
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Posted 08/07/12
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#3
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My first thought would be brain tumor or stroke. did the mri just do the spine or did they do the head also?? It looks like you are n a catch 22 situation, I have had it with a couple of my older dogs in the past, the meds for the heart hurt the liver, the meds for the liver hurt the heart and kidneys.. I wish you the very best, and for dieal also.
__________________ Ranchlands Mastiffs
http://www.ranchlandsmastiffs.com
Member MCOA, SSMF, FAME
Rescue Volunteer SSMR
If you dont rescue, Dont Breed.
We can't solve problems by using the same kind of thinking we used when we created them.
Albert Einstein
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eting
Registered: 08/07/12 Posts: 3
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Posted 08/07/12
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#4
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Thanks for the good wishes. Purdue says that it must be something inflammatory because the steroid helped, but as we have decreased it he has regressed again. Everyone seems to be at a loss. They did an MRI of the head and as much of the spine as they could....the machine was too small for him and they claimed they didn't have an MRI machine at the large animal hospital. We just want our big boy to get better....the thought of losing him is almost unbearable....
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erikam
Registered: 01/21/12 Posts: 1,530
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Posted 08/07/12
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#5
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They're full of S**T and I would kick up fuss at Purdue - see if you can move to another specialist there -
http://news.discovery.com/animals/huge-medical-devices-service-large-animal-patients.html
Huge Medical Devices Service Large Animal Patients
 - Analysis by Jennifer Viegas
Mon May 10, 2010 12:05 PM ET () Comments | Leave a Comment - Print
- Email
Thanks to enormous new MRI and tomography machines that can fit large patients, horses and other big animals are receiving improved medical care. Over the past several months, the technology has been integrated into animal practices, with Purdue University School of Veterinary Medicine being the latest to add an MRI machine to its Veterinary Teaching Hospital.
__________________ http://www.kyniska.com
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erikam
Registered: 01/21/12 Posts: 1,530
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Posted 08/07/12
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#6
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"Purdue will be using the first equine-capable, high-field-strength, magnetic resonance imaging unit in Indiana," said Mimi Arighi this week. She's an associate professor and director of the Veterinary Teaching Hospital. Arighi added, "The MRI is instrumental in diagnosing a variety of conditions, many of which cannot be detected using other forms of diagnostic imaging, in small and large animals. This machine and its new suite, as well as the new adjacent computed tomography suite, allows us to improve the care we provide animals." This is no ordinary MRI unit. The full suite takes up more than 1,100 square feet, which allows for the horse, or other animal patient, and needed medical staff. "The MRI uses strong magnetic fields and radiofrequency pulse to produce images with superior soft tissue contrast and excellent detail," said James Naughton, a clinical assistant professor of radiology. "This imaging technology will facilitate the diagnosis of cancer and developmental and inflammatory disease of the brain, skull and spinal column in animals of all sizes. We also will be able to assess the extent of soft tissue disease and cancer for surgical and radiation therapy planning and treatment. It also will be used in the diagnosis of disease in the head and lower limbs of large animals, most commonly the horse." At present, the diagnostic imaging section is examining 17 small animals per month, with about 4 large animals per month anticipated from now on. It's not an easy effort. Large animals receiving an MRI must be anesthetized and placed on a non-magnetic table that has been specially designed and built for animals that weigh more than 500 pounds. The same services can be offered for cattle, sheep, goats, pigs, llamas and alpacas.
__________________ http://www.kyniska.com
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erikam
Registered: 01/21/12 Posts: 1,530
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Posted 08/07/12
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#7
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You might want to try Michigan if it is not too far from you, if you feel purdue it not being agressive enough ... http://cvm.msu.edu/hospital/services/diagnostic-imaging
__________________ http://www.kyniska.com
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OsoBodacious

~ POWER POSTER ~
Registered: 09/24/07 Posts: 1,330
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Posted 08/07/12
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#8
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The symptoms and treatment you describe sound exactly like what my boy, Grizzly, went through. He was originally diagnosed with Idiopathic Vestibular Disease and treated accordingly.
Long story short, he was ultimately diagnosed with Gastric Lymphoma w/ Paraneoplastic Neurological Syndrome.
What this is, is lymphoma (cancer) of the digestive tract. The neurological symptoms were not caused by metastases to the brain, but rather by proteins produced by the cancer that cause malfunction in the brain.
He was seen by the Neurology department at Auburn and they could not determine the cause. He was then seen by the Internal Medicine department who found the thickening of his stomach wall, did surgery, and from the pathology found the cancer.
Grizzly had numerous tests done prior to the exploratory surgery and NONE indicated cancer. The cancer was not found until after a portion of his stomach was removed and sent to pathology.
This could at least give you another avenue to pursue for answers.
__________________ Terri Perkins
http://www.osobodaciousmastiffs.com
Member: MCOA, SSMF, SEAKC
Volunteer - SSMR
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BlusMom

Registered: 03/23/12 Posts: 438
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Posted 08/07/12
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#9
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Here is the link I used to find Blu's neurologist. This breed keeps it pretty well updated and I sahre it all teh time. These are canine neurologists who are used to his sort of thing. I know the university's are good but budgets are tight and university's are scaling back. Sad to say. http://www.cavalierhealth.org/neurologists.htm
hope it helps and you have my sympathies I know EXACTLY what you are going through.
__________________ Theresa
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GinaG
POWER POSTER
Registered: 04/09/09 Posts: 3,005
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Posted 08/07/12
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#10
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I can't offer anymore than the wonderful girls said above...only that I hope you get some answers and you and Deizel are in my thoughts and prayers ...8 is a tough age to go through any health issues..you are a kind on loving owner and I wish you all the best. hugs to you and your beastie.. Gina
__________________ gina anelli
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Jeanine

Registered: 06/09/12 Posts: 74
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Posted 08/07/12
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#11
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I'm so sorry you and Diezel and having such difficulty. There are excellent suggestions and possibilities outlined here. One of our dogs, a female brindle developed the same symptoms and some others as time went on. After several go rounds with specialists/etc...our regular vet did a liver function test. The results were so strange she began a series of other tests and found Nellie had a liver shunt disorder (basically her liver was unable to process wastes any longer and was too small and atrophied). Steroids helped as did a combination of meds.
It's just another thought. Have them do liver and pancreatic function tests. We cut down on the protein and fats and Nellie lived 7 years. Good luck.
__________________ Jeanine
Misty Hollow
Mistyhollowmastiffs@gmail.com
“Until one has loved an animal, a part of one's soul remains unawakened.” Anatole Frances
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eting
Registered: 08/07/12 Posts: 3
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Posted 08/07/12
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#12
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Thank you so much everyone! This has given me a lot of "food for thought." My husband and I will be contacting Purdue to discuss the MRI situation. 8 is a hard age because he isn't a young pup anymore but we just can't bare to feel like we gave up on him. I'm so glad I posted on this blog. If anyone thinks of anything else please let me know. We are open to ALL suggestions
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gallantmastiff
Registered: 03/12/08 Posts: 111
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Posted 08/07/12
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#13
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One of my puppy people had a similar incidence just this past week. Her Brandy 5yrs has osteo arthrits and this past Mon, she could not get up. They rushed her to vet's her white blood cell count was over thetop and her tep was 108, so they rushed her to Emerg Clinic in Toronto. Seen by neurologist, that was ruled out, she had a severe infection and they determined immune mediated polyarthritis. Google this, it may be what Diesel has also. She is home now, but is on prednisone and of course antibiotics. I had never heard of this, but gee we all learn don't we?
Hope you find out soon. Cheers,
__________________ CONNIE HACHEY
GALLANT MASTIFFS
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erikam
Registered: 01/21/12 Posts: 1,530
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Posted 08/10/12
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#14
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any update ?
__________________ http://www.kyniska.com
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