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LindaGreesonRice

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Reply with quote  #1 
Ok peeps, it is time to get this information out in the open so
we can be tracking pedigrees and try and figgure out where this
awful disease comes from.. Please do not post any dogs names
unless you are ABSOLUTELY sure that they were Cystinuria Positive.
 (I am speaking of long deceased dogs -
all others should be posted as per rules below.)

If you were/are the owner of the dog listed, please put your
name down as the owner. Sire and dam of the affected dog
would be helpful too.

PLEASE put the source of your information after any dog listed..

 whether it be direct info from the owner or posted on a website,

. We don't want to list any dogs that are not positive.

Dogs should ideally be listed by their owner or their breeder...

 NO RUMORS PLEASE. ONLY DUPLICATE OF WEB POSTINGS
 
WITH DIRECT LINK TO THE WEBSITE WHERE IT IS POSTED!


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Linda Greeson Rice
AKC Breeder of Merit

The Mastiff Sweet Spot
http://www.bluequaker.com/Mastiffs.htm



We do not breed often, but we do our best to breed top quality mastiffs
with excellent pedigrees to back them up. All breedings are carefully planned to produce
the very best mastiffs, sound in both body and mind, beautiful and strong,
representing the true mastiff standard.

We fully test our dogs. We believe that a person that "just wants a pet" has a right
to own a beautiful, well bred dog that is sound and healthy
every bit as much as someone wanting a "show dog".
Sandragon

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Reply with quote  #2 
This is Danny Boy. The dog that the Danny Fund was set up to honor!
He was owned by Bill Newman.

 

                                        CERTIFIED PEDIGREE
Registered Name:  Renrock Danny Boy O'Nanjay
Reg. #: WP789833/06   Sex: Male   Date Whelped: 7/1/1997   Color: ______________________________
Notes: MCOAsp98
                                  -Ch. Deer Run Wycliff
                      -Ch. Deer Run Ivan
                      |           -Tasha Farley's First Lady
              -Ch. Deer Run Ezekiel
              | OFA MF426     |           -Ch. Grand Duke O'Fern
              |           -Le Mar's Sally
              |                       -Le Mar's Little Gem
  -Ch. Old School Primo Remo Major
  | Thyroid Normal    |                       -Ch. Deer Run Noah Massalane
  |           |           -Deer Run Florister Rufus
  |           |           |           -Ch. Nanjemoy's Etasha
  |           -Ch. Old School Ursa Major
  |                   |           -Ch. Hannibal of Makar
  |                   -Old School Trouble
  |                               -Mistress Julia of Massalane
-Nanjay's Black Star In MyCrown
| |                               -Ch. Gulph Mills Mugger
| |                   -Ch. Gulph Mills Mulcher
| |                   |           -Ch. Greenbranch Macushla
| |           -Ch. Gulph Mills Ajax III
| |           |           |           -Tamarack Donner
| |           |           -Ch. Lady Natassia Of Apple Creek
| |           |                       -Ch. Lady Pebbles Of Apple Creek
| -Nanjay's Black Jewel Of Lyndon
|             |                       -Ch. Bournewood Edwin
|             |           -Ch. Harper of Lyndon
|             |           | OFA MF-282        -Ch. Oak Ridge's Aquila
|             -Lyndon Window Chimes Lyra
|           OFA good MF577G30F|           -Peach Farm Jacob
|                     -Jacob's High Buttons
|                       OFA MF-299-T      -Jalaine Daisy
-
 
|                                 -Ch. Deer Run Ezekiel
|                     -Ch. Burns Hall Zackery
|                     | OFA good MF1175G42M CERF-Ch. Thorchelseaias Noel
|             -Am.Can.Ch. Matts Joshua Of Dogwood Knoll
|             |           |           -Rapscallion's Sir Winston
|             |           -Ch. Burns Hall Nicole
|             |             OFA fair MF1223F53F-Ch. Night Stalker Sarah Anne
| -Ch. Lionsire Run'n Bear Samson
| | OFA excellent MF2003E28M|                     -Ch. Deer Run Ivan
| |           |           -Ch. Deer Run Ezekiel
| |           |           | OFA MF426         -Le Mar's Sally
| |           -Lionsire Girl With The Curl
| |                   |           -Sheila's Christian Samson
| |                   -Christian Bristol Cream
| |                               -Ch. Zachary's Lady Titan
-Running Bear's Rogue Of Nanjay
  |                               -Ch. Altom's Paulas Pride
  |                   -Emphil's Montana Of Wildacres
  |                   |           -Emeline Mayflower of Columbo
  |           -General Lee Bigfoot
  |           |           |           -Sir Cassius Of Rockcliff
  |           |           -Sara Lee Wycliff
  |           |                       -Babe Ruth
  -Gabriela's Abbilene
              |                       -Ch. Willowledge Caius
              |           -Vegte's Milo Of Belly Acres
              |           |           -Ch. Camelot's Rock Of Gibraltor
              -Elaine's Daisey Magnolia
                      |           -Samuel Jaws Easter
                      -Vegte's Tooty Of Belly Acres
                                  -Princess Of Coldwater
I hereby certify that this pedigree is true and correct to the best of my knowledge and belief
Signed By: __________________________________________________  Signature: __________________________________________________
Date: ______________________________  Address: ___________________________________________________________________________




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Fanchone1

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Reply with quote  #3 
My boy is positive:

CH Windfall's Full of Gusto
Damn:  CH Windfall's Tangerine Dream
Sire:  CH Greco's Titan I Did it My Way

He tested positive this past May but prior to that he tested negative!  Everyone, PLEASE, test your dogs regularly and support research so we can put a stop to this terrible disease!  Thanks!

Kristine Newton
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Reply with quote  #4 

Attached Images
Click image for larger version - Name: INT_AM_CH_HERAS_KING_ZUES_(2).jpg, Views: 8522, Size: 465.77 KB 

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RollingRock

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Reply with quote  #5 
My dog is also Cystinuria Positive.  He is the littermate to above Windfall's Full of Gusto.

Name: Windfall's Trophy Buck
Damn: CH Windfall's Tangerine Dream
Sire: CH Greco's Titan I Did it My Way

Thanks ladies!  This is a wonderful idea.  Love to see us all coming together.
Kim

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medievalmastiff

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Reply with quote  #6 
  This the first C+ boy.  The second is out of his littermate sister.
       
         LisaG
 
                                                    Ch. Acorn Hill Uther Pendragon CGC TDI
                                             Ch Acorn Hill Silent Night
                                                      Ch Lionsire Indigo of Pax River
                            Ch Acorn Hill Nite to Remember
                                                      Ch. Iron Hills Warwagon
                                              Ch Acorn Hill Mountain Laurel
                                                         Arrabelle of Acorn Hill CD
               Darksides Battle Wagon
                                                      Ch Deer Run Semper Fi THor CD
                                              Ch Iron Hills Portfolio
                                                      Ch Iron Hills Earned Interst
                            Darkside Tyngors Sexy Sadie
                                                      Ch Iron Hills Once Upon a Wagon
                                              Ch Iron Hills Color My Wagon
                                                       Caledonia Lady Di
Medievals Finn McCool
                                                       Ch Iron Hills Warwagon
                                             Ch Acorn Hill Uther Pendragon CGC TDI
                                                       Arrabelle of Acorn Hill CD
                            Ironclads Unknown Rider
                                                      Ch Iron Hills Into the Night
                                            Iron Hills Ironclad Alibi
                                                      Ch Iron Hills Fixin to Start
               Ch. Ironclad Darkside Shade of Night
                                                      Ch Iron Hills Warwagon
                                          Iron Hills Once Upon a Wagont
                                                     Ch Lionsire Indigo of Pax River
                            Pattersons NS Prime Rate
                                                      Ch Old Schools Primo Remo Major
                                          Night Stalker Prima Remot
                                                      Night Stalker Abby

Teresa

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Reply with quote  #7 

Pedigree for Newt

Sire
Ch CC Giganti Napolean
Sire
Ch Southports Prime Time
Sire
Ch Iron Hills Warwagon
Sire
Ch Lionshire Ironhill Warleggen
Dam
Ch Iron Hills Elbereth
Dam
Ch Southports Daisy Quarters
Sire
Ch Stonebrook Southports Byron
Dam
Ch Southports Red Rose
Dam
Ch CC Fergie of SidetrackC
Sire
Kidds Knight Michael
Sire
Ch. Castle Mounts Atlas
Dam
Castle Mount Moonlight Matti
Dam
Iron Hills Sidetrack Katydid
Sire
Rocky Hill Alexander
Dam
Iron Hills Jewel of War
Dam
Ch Tejas Giganti Alexis
Sire
Ch Tejas Ironman Tyson
Sire
Ch Groppetti's Wallon
Sire
Daultons Sir Henry Tizard
Dam
Ch Deer Run Groppetti Fahn Loni
Dam
Ch Gulph Mills Tejas Magic
Sire
Berengarias Gulph Mills Pal
Dam
Ch Gulph Mills Glory Be
Dam
Tejas Ali's Clancy
Sire
Ch Southports Bloack Orpheus
Sire
Ch Stonebrook Southports Byron
Dam
Ch P-Js Athena
Dam
Ch Tejas Pal of My Heart
Sire
Groppetti's Wallon
Dam
Ch Gulph Mills Tejas Magic

This pedigree page was built for free at SitStay.com Get your Dog Supplies at SitStay.com


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LindaGreesonRice

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Reply with quote  #8 
This may seem redundant, but I think this post, written by
Tracy eberheart of Ranchlands Mastiffs, is so good that it
deserves repeating, especially on this thread.

Thank you Tracy!

Cystinuria genetics – Tracy Eberheart

With the mode of transmission still incomplete, and the models that follow may

 have another factor UPenns recommendations are pretty clear. The still believe

 it to be x linked recessive with incomplete penetrance ( this would be the reason

 that you would not see as many positives out of the littler as you would expect.)

 there is another factor in play, and It is my understanding that there may be

studies coming in soon that would link the xfactor recessive with the coupling with

 the other factor ( I will not say until the studies prove it so but it may be related to

 a factor many have not considered yet) so UPENN recommendations of ..........

Now let us consider the possible outcomes of different types of matings, assuming

simple X-linked inheritance of the disease.


• Normal female to normal male – This type of mating will produce only normal offspring.


Carrier female to normal male - When a carrier female is bred to a normal male,

the sons who receive their mother’s mutant version of the gene, also referred to as the

 mutant allele, will have the disease, since their only copy of the gene is a mutant version

. The sons who get her normal allele will be normal. Therefore, on average, 1/2 of the

 sons will be normal, and 1/2 will be affected. The daughters of the carrier female by

normal male breeding will all get a normal allele from their normal father. They will get

 either a normal allele or a mutant allele from their mother. Therefore, while all of the

 daughters will be clinically normal, approximately 1/2 of them will be carrier females.

 There are two important issues to consider here.

 

o The proportion 1/2 stated above is an average. Each offspring has a 50:50 chance of

getting the mutant allele from the mother. Consequently, it is possible, by chance, that a

 carrier mother will not give her mutant allele to ANY of her offspring, particularly, if she

does not produce many pups. (Think of tossing a coin for example three times and

getting three heads in a row. You wouldn’t be too surprised.) Consider a litter of six,

containing three females. If, by chance, none of the three male puppies received a mutant

 allele from their carrier dam, this carrier female would not be recognized as a carrier

 because she did not produce any affected offspring, and her daughters would not be

 recognized as being at risk of being carriers themselves.


o Since a carrier female is indistinguishable from a normal female, without any additional

 information, there is no way to know if the normal-appearing female is normal or a carrier.

In the case of cystinuria, the only way to identify a carrier female is from knowledge of her

parents or offspring. If a female had an affected parent, she is an obligate carrier, having

only the possibility of getting a mutant allele from that parent. Or, if the female produced

an affected offspring, that offspring had to get a mutant allele from the mother, making her

a carrier. This emphasizes why family information is so important.

 

Normal female to affected male – The normal female can only contribute normal alleles

to her offspring, while the affected male contributes his only X chromosome, which carries

the mutant allele, to all of his daughters, and contributes his Y chromosome to his sons.

Therefore, all males produced from this type of mating will be normal and ALL females

produced will be CARRIERS. Important issues here are:

o Carrier and normal females are indistinguishable, so without additional information, it

would not be possible to know if the normal-appearing female used for mating was

 normal or a carrier.


o The daughters of an affected male are obligate carriers, because all daughters get their

 father’s only X chromosome, which has a mutant allele in an affected male. This is a case

where additional information allows us to differentiate between normal and carrier females.

• Affected female to normal male – The affected female has only mutant alleles to

contribute to her offspring, and the normal male has only normal alleles. Consequently,

 ALL male puppies are AFFECTED (they get their X chromosome from their mother),

and ALL female offspring are CARRIERS. Remember that:

o Due to anatomical differences, unlike affected males, affected females are much less

likely to form stones that will cause clinical problems, and in the absence of urine testing,

are very likely to be undetected.

Carrier female to affected male – Here, the mother contributes either a mutant allele, or a

 normal allele, while the father has only a mutant allele to contribute. On average, 1/2

of the daughters will be affected and 1/2 will be carriers. Of the sons, on average, 1/2

will be affected and 1/2 will be normal. Therefore, on average, 1/2 of any litter will be affected.

The important issues are:

o As explained above, the 1/2 ratios are the average that would be seen from this type of mating.

 Within a single litter, the actual ratios will vary. Litters from this type of mating could range from

 containing no affected dogs to containing all affected dogs.


o Affected females can be produced, even when a disease shows X-linked inheritance.

• Affected female to affected male – All offspring will be affected. In the case of cystinuria,

 they may not all form stones or develop clinical signs of the disease.

o This is a good place to reiterate the additional complications present for cystinuria in particular.

 In the case of cystinuria, we know that there can be cystinuric dogs without uroliths, and that

uroliths often form for the first time after a dog has been bred. For both of these cases,

 mutant alleles that are not detected in the parents are passed from parent to offspring.

The bottom line is that the breeding of affected dogs of either gender or of carrier females will

transmit mutant alleles to offspring and may produce cystinuric animals. Complicating factors

in making breeding decisions are the facts that we do not yet have any estimate of the rate at

which dogs with excess cystine in the urine develop clinical manifestations of the disease. We

do know that dogs that have had only negative NP test results have formed cystine stones.

 What this tells us is that, presumbably due to the variability of cystine levels in the urine

, a single or even a few NP test results do not necessarily give a complete understanding

 of renal cystine transport in a dog.

 

If a dog is found to be positive it should not be bred period, I dont really care that you have built a

 line on it. With the mode of inheritence more than likely x linked recessive with a cofactor

 influencing it, the siblings should also be spayed/neutered, they are more than likely carrying

 the mutant gene, and the expression of that gene is dependant on the cofactor being expressed also.

 It is hard enough every day to take care of these big guys, foods, regular vet expenses ect,

why throw in a known problem in the mix??


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Ranchlands Mastiffs



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Linda Greeson Rice
AKC Breeder of Merit

The Mastiff Sweet Spot
http://www.bluequaker.com/Mastiffs.htm



We do not breed often, but we do our best to breed top quality mastiffs
with excellent pedigrees to back them up. All breedings are carefully planned to produce
the very best mastiffs, sound in both body and mind, beautiful and strong,
representing the true mastiff standard.

We fully test our dogs. We believe that a person that "just wants a pet" has a right
to own a beautiful, well bred dog that is sound and healthy
every bit as much as someone wanting a "show dog".
Sandragon

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Reply with quote  #9 

Registered Name: Windfalls Trophy Buck
Reg. #: WS154382/08   Sex: Male   Date Whelped: 11/10/2005   Color: fawn
Notes: 061*793*529,CERF,vWD98%,CYSTN
                                                              -Eng.Ch. Copenore Rab
                                          -Eng.Ch. Hollesley Medicine Man
                                          |                       -Eng.Ch. Devil Dancer of Hollesley
                      -Ch. Falmorehall Fortescue
                      |                           |                       -Eng,Irish Ch. Langton Of Fallmore
                      |                           -Irish.Ch. Falmorehall Call Me Madam
                      |                                               -Bellabees Mynydd Perfydd
  -Ch. Greco's Hollesley Rogue
  |                       |                                               -Ch. Meps Tristan
  |                       |                           -Greco's Tristan Son
  |                       |                           |                       -Brookmoor's Sadie Antonette
  |                       -Greco's Hollesley Trist Jean
  |                                           |                       -Greco's Daniel
  |                                           -Greco's Hollesley Trixie
  |                                                               -Ullery's Princess Ann
-Ch. Greco's Titan I Did It My Way
| |OFA fair MF2279F25M OFEL CERF                               -Ch. Nelson of Hollesley
| |vWD Clear                                   -Greco's Daniel
| |                                           |                       -Greco's Dominic
| |                       -Ch. Greco's Hollesley Sam
| |                       |         OFA fair MF-785F71M|                       -Ch. Nelson of Hollesley
| |                       |                           -Princess Dominic
| |                       |                                               -Greco's Star
| -Greco's Saint Gertrude
|                       |                                               -Ch. Nelson of Hollesley
|                       |                           -Greco's Daniel
|                       |                           |                       -Greco's Dominic
|                       -Greco's Hollesley Maid
|                                           |                       -Ch. Nelson of Hollesley
|                                           -Princess Dominic
|                                                               -Greco's Star
-

|                                                               -Brawnson The Majestic
|                                           -Sir Buckingham Of Navajo Run
|                                           | OFA good MF1848G30M-Emma Lyonhurst Enchantress
|                       -Ch. Lyonhurst Orson ,CGC
|                       |         OFA good MF2705G25M OFEL CERF|               -Lyonhurst Roc Of Castlemount
|                       |         vWD Clear Thyroid Normal -Lyonhurst Regina
|                       |                             OFA good MF1182G25F-Lyonhurst Forever Ember
| -Ch. Lyonhurst Howie Huge
| | OFA good MF4209G24M OFEL CERF|                               -Ch. Haydens Gulliver ,CD,CGC,TDI,TT
| | vWD Clear               |                           -Ch. Sir Oliver Of Evergreen
| |                       |                           |                       -Evergreen Willowledge Sandy
| |                       -Lyonhurst Spur Of The Moment
| |                         OFA good MF3315G24F OFEL|               -Ch. Roco Of Sir Grizzleys
| |                                           -Ginnie Alexandria Beethoven
| |                                             OFA good MF1713G33F-Princess Alexandria Hanover
-Ch. Windfalls Tangerine Dream
  |OFA fair MF6739F34F OFEL CERF                               -Ch. Falmorehall Fortescue
  |vWD Clear                                   -Ch. Greco's Hollesley Rogue
  |                                           |                       -Greco's Hollesley Trist Jean
  |                       -Greco's Nigel Of Northampton
  |                       |         OFA good OFEL CERF|                       -Brezy Points Sampson
  |                       |                           -Greco's Saint Bernadette Holl
  |                       |                                               -Brezy Points Deliah
  -Windfalls Queen OfTheValkyries
    OFA good MF4868G26F OFEL CERF|                               -Haus Humboldt Black Jack
    vWD Clear               |                           -Monarch's Black Sun Rising
                      |                           | OFA good MF2297G24M CERF-Haus Humboldt Silver's Chanti
                                            vWD Clear Thyroid Normal -Monarch's Jewel Of Windfall
                        OFA fair MF3166F24F OFEL CERF|               -Sir Grizzley's Sir Romeo
                        vWD Clear           -Am.Can.Ch. Monroe's Queen Antigone ,TT,CGC,TDI
                                            OFA good MF1661G25F OFEL CERF-Coburngore Courtney
I hereby certify that this pedigree is true and correct to the best of my knowledge and belief
Signed By: __________________________________________________  Signature: __________________________________________________
Date: ______________________________  Address: ___________________________________________________________________________


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Sandragon Mastiffs
Where Mastiffs and Dragons play!
http://sandragonmastiff.com


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Sandragon

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Reply with quote  #10 

Registered Name: De Vine Farm's Hooch
Reg. #: WP319523/02   Sex: Male   Date Whelped: 10/6/1990   Color: dark brindle
Notes: OFAf MF1308F28M,OFEL MF50,CERF317\23&65,mVWD92%,THYRNB1-11,cystPositive
                                                              -Eng.Ch. Hollesley Medicine Man
                                          -Eng.Ch. Honeycroft Danny Boy
                                          |                       -Eng.Ch. Honeycroft Crismas Cracker
                      -Eng.Ch. Bulliff Razzermataz
                      |                           |                       -Eng.Ch. Presidents Lad of Bulliff
                      |                           -Bulliff Giselt
                      |                                               -Eng.Ch. Astelle Oven Ready of Bulliff
  -Bulliff Butchers Blade
  |                       |                                               -Ranulf of Bulliff
  |                       |                           -Khan of Bulliff
  |                       |                           |                       -Monterosa Lovely Lady
  |                       -Bulliff Vagabond
  |                                           |                       -Eng.Ch. Presidents Lad of Bulliff
  |                                           -Bulliff Tarbaby
  |                                                               -Bulliff Queen Aelfgifu
-Ch. Willowledge Brett
| |vWD Clear                                                       -Bournewood Jasper
| |                                           -Ch. Bournewood Edwin
| |                                           |                       -Bournewood Sophie
| |                       -Willowledge Woodrow
| |                       |                           |                       -Alauntes Baron
| |                       |                           -Alauntes Rose
| |                       |                                               -Alauntes Glori
| -Willowledge Pollianna
|                       |                                               -Ch. Deer Run Jericho City
|                       |                           -Ch. Deer Run Wycliff
|                       |                           |                       -Deer Run Stella
|                       -Pippin of Bearhill
|                                           |                       -Ch. Willowledge Clyde of Essex
|                                           -Ch. Reveille Arwen Evenstar
|                                             OFA MF-133-T      -Ch. Reveille By Candlelight
-

|                                                               -Ch. Deer Run Wycliff
|                                           -Ch. Deer Run Ivan
|                                           |                       -Tasha Farley's First Lady
|                       -Ch. Deer Run Ezekiel
|                       |         OFA MF426           |                       -Ch. Grand Duke O'Fern
|                       |                           -Le Mar's Sally
|                       |                                               -Le Mar's Little Gem
| -Ch. Old School Majestic Major
| |                       |                                               -Ch. Deer Run Noah Massalane
| |                       |                           -Deer Run Florister Rufus
| |                       |                           |                       -Ch. Nanjemoy's Etasha
| |                       -Ch. Old School Ursa Major
| |                                           |                       -Ch. Hannibal of Makar
| |                                           -Old School Trouble
| |                                                               -Mistress Julia of Massalane
-Old School Peersleigh Muffin
  |OFA good MF966G29F CERF                                       -Master of the Woods
  |vWD Clear Thyroid Normal                   -Ch. Odin of Dahlseide
  |                                           |                       -Dahlseide Dame Puddin-Tame
  |                       -Ch. Peersleigh Storm Sherman
  |                       |                           |                       -Ch. Willowledge Caesar III
  |                       |                           -Ch. Peersleigh Princess Carolyn
  |                       |                                               -Peersleigh Lady Lorelei
  -Ch. Storm English Legacy
                      |                                               -Ch. Harold of Shute
                      |                           -Ch. Griffith's T. Geronimo
                      |                           |                       -Ch. Sun-Belle's Muggs McGinnis
                      -Willowledge Meredith
                                          |                       -Ch. Willowledge Big City Ben
                                          -Ch. Willowledge Katrina
                                                              -Ch. Willowledge Marya ,CD
I hereby certify that this pedigree is true and correct to the best of my knowledge and belief
Signed By: __________________________________________________  Signature: __________________________________________________
Date: ______________________________  Address: ___________________________________________________________________________


__________________
Lorie
Sandragon Mastiffs
Where Mastiffs and Dragons play!
http://sandragonmastiff.com


This post may not be forwarded, copied, transmitted, or reprinted without the permission of the sender!
Sandragon

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Reply with quote  #11 

To whom it may concern:

The brindle English Mastiff "Justinlove" (pedigree attached; known to
us as "Bogart") was abandoned by his original owner at the age of
approximately 18 months and was adopted by us through English Mastiff
Rescue in 2000.  We owned Bogart continuously from then until May,
2007, when he was euthanized for advanced bone cancer.

Bogart was diagnosed with cystinuria in 2000, was determined to be a
stone-former, and received a urethrostomy.  He had no further urinary
problems for the remainder of his life.

We hereby give permission for Bogart's pedigree, and/or medical
records, and/or any other information about him, to be used in any
way that advances our knowledge of the cause(s) of, and potential
treatments for, cystinuria.

             -Ch. Deer Run Ezekiel
                                          -Ch. Old School Sergeant Major                                         | OFA good MF712G35M--Ch. Old School Ursa Major                 -Ch. Old School Sgt Major's Sagar
                      |         OFA fair MF2064F66M OFEL|               -Ch. Autumn River Big Ben
                      |                           -Old School Ben's Autumn Major
                      |                                               -Ch. Old School Ursa Major
  -Old School Tintagel's Blake
  | OFEL CERF               |                                               -Farnaby Fidelity
  |                       |                           -Ch. Banyon's Fozzie Bear
  |                       |                           |                       -Ch. Banyon's Charmin
  |                       -Ch. Tintagel's Oreo
  |                         OFA fair MF1233F56F|                       -Ch. Deer Run Ezekiel
  |                                           -Old School Ski Of Tintagel
  |                                                               -Ch. Old School Ursa Major
-Old School Handsome Harley D
| |CERF                                                               -Ch. Deer Run Ivan
| |                                           -Ch. Deer Run Ezekiel
| |                                           | OFA MF426               -Le Mar's Sally
| |                       -Ch. Old School Majestic Major
| |                       |                           |                       -Deer Run Florister Rufus
| |                       |                           -Ch. Old School Ursa Major
| |                       |                                               -Old School Trouble
| -Ch. Old School Lady Portia
|                       |                                               -Ch. Deer Run McMunger
|                       |                           -Ch. Old School Panama Red
|                       |                           |                       -Ch. Old School Ursa Major
|                       -Ch. O'School Blacknight Madalene
|                                           |                       -Ch. Hannibal of Makar
|                                           -Ch. Blacknights Victoria O'School
|                                                               -Verdune's Darling Lilly
-

|                                                               -Ch. Deer Run Wycliff
|                                           -Ch. Deer Run Ivan
|                                           |                       -Tasha Farley's First Lady
|                       -Ch. Deer Run Ezekiel
|                       |         OFA MF426           |                       -Ch. Grand Duke O'Fern
|                       |                           -Le Mar's Sally
|                       |                                               -Le Mar's Little Gem
| -Ch. Old School Sergeant Major
| | OFA good MF712G35M-|                                       -Ch. Deer Run Noah Massalane
| |                       |                           -Deer Run Florister Rufus
| |                       |                           |                       -Ch. Nanjemoy's Etasha
| |                       -Ch. Old School Ursa Major
| |                                           |                       -Ch. Hannibal of Makar
| |                                           -Old School Trouble
| |                                                               -Mistress Julia of Massalane
-Ch. Justinlove Heaven Sent
  |OFA fair MF2119F24F OFEL CERF                               -Ch. Deer Run Wycliff
  |                                           -Ch. Deer Run Max A Million III
  |                                           |                       -Deer Run Philipa
  |                       -Ch. Austin Healy Whiting
  |                       |                           |                       -Ch. Deer Run McMunger
  |                       |                           -Von Roth's Nicolette
  |                       |                                               -Ch. Von Roth's Lady Gwenivere
  -Justinlove My Sweet Abigail
                      |                                               -Ch. Royalcourt Jonah
                      |                           -Ch. Willowledge Recon Sniper ,CD
                      |                           |                       -Royalcourt Jesabelle
                      -Gold Coasts Ruffian
                                          |                       -Ch. Southerns Lord Buttercup
                                          -Southerns Shady Lady
                                                              -Kirrmans Southern Lady
I hereby certify that this pedigree is true and correct to the best of my knowledge and belief
Signed By: __________________________________________________  Signature: __________________________________________________
Date: ______________________________  Address: ___________________________________________________________________________


__________________
Lorie
Sandragon Mastiffs
Where Mastiffs and Dragons play!
http://sandragonmastiff.com


This post may not be forwarded, copied, transmitted, or reprinted without the permission of the sender!
Sandragon

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Reply with quote  #12 




                                       
Registered Name: Windfalls Full Of Gusto
Reg. #: WS154382/07   Sex: Male   Date Whelped: 11/10/2005   Color: fawn
Notes: 061*792*614,CERF,vWD106%,CYSTN
                                                              -Eng.Ch. Copenore Rab
                                          -Eng.Ch. Hollesley Medicine Man
                                          |                       -Eng.Ch. Devil Dancer of Hollesley
                      -Ch. Falmorehall Fortescue
                      |                           |                       -Eng,Irish Ch. Langton Of Fallmore
                      |                           -Irish.Ch. Falmorehall Call Me Madam
                      |                                               -Bellabees Mynydd Perfydd
  -Ch. Greco's Hollesley Rogue
  |                       |                                               -Ch. Meps Tristan
  |                       |                           -Greco's Tristan Son
  |                       |                           |                       -Brookmoor's Sadie Antonette
  |                       -Greco's Hollesley Trist Jean
  |                                           |                       -Greco's Daniel
  |                                           -Greco's Hollesley Trixie
  |                                                               -Ullery's Princess Ann
-Ch. Greco's Titan I Did It My Way
| |OFA fair MF2279F25M OFEL CERF                               -Ch. Nelson of Hollesley
| |vWD Clear                                   -Greco's Daniel
| |                                           |                       -Greco's Dominic
| |                       -Ch. Greco's Hollesley Sam
| |                       |         OFA fair MF-785F71M|                       -Ch. Nelson of Hollesley
| |                       |                           -Princess Dominic
| |                       |                                               -Greco's Star
| -Greco's Saint Gertrude
|                       |                                               -Ch. Nelson of Hollesley
|                       |                           -Greco's Daniel
|                       |                           |                       -Greco's Dominic
|                       -Greco's Hollesley Maid
|                                           |                       -Ch. Nelson of Hollesley
|                                           -Princess Dominic
|                                                               -Greco's Star
-

|                                                               -Brawnson The Majestic
|                                           -Sir Buckingham Of Navajo Run
|                                           | OFA good MF1848G30M-Emma Lyonhurst Enchantress
|                       -Ch. Lyonhurst Orson ,CGC
|                       |         OFA good MF2705G25M OFEL CERF|               -Lyonhurst Roc Of Castlemount
|                       |         vWD Clear Thyroid Normal -Lyonhurst Regina
|                       |                             OFA good MF1182G25F-Lyonhurst Forever Ember
| -Ch. Lyonhurst Howie Huge
| | OFA good MF4209G24M OFEL CERF|                               -Ch. Haydens Gulliver ,CD,CGC,TDI,TT
| | vWD Clear               |                           -Ch. Sir Oliver Of Evergreen
| |                       |                           |                       -Evergreen Willowledge Sandy
| |                       -Lyonhurst Spur Of The Moment
| |                         OFA good MF3315G24F OFEL|               -Ch. Roco Of Sir Grizzleys
| |                                           -Ginnie Alexandria Beethoven
| |                                             OFA good MF1713G33F-Princess Alexandria Hanover
-Ch. Windfalls Tangerine Dream
  |OFA fair MF6739F34F OFEL CERF                               -Ch. Falmorehall Fortescue
  |vWD Clear                                   -Ch. Greco's Hollesley Rogue
  |                                           |                       -Greco's Hollesley Trist Jean
  |                       -Greco's Nigel Of Northampton
  |                       |         OFA good OFEL CERF|                       -Brezy Points Sampson
  |                       |                           -Greco's Saint Bernadette Holl
  |                       |                                               -Brezy Points Deliah
  -Windfalls Queen OfTheValkyries
    OFA good MF4868G26F OFEL CERF|                               -Haus Humboldt Black Jack
    vWD Clear               |                           -Monarch's Black Sun Rising
                      |                           | OFA good MF2297G24M CERF-Haus Humboldt Silver's Chanti
                                            vWD Clear Thyroid Normal -Monarch's Jewel Of Windfall
                        OFA fair MF3166F24F OFEL CERF|               -Sir Grizzley's Sir Romeo
                        vWD Clear           -Am.Can.Ch. Monroe's Queen Antigone ,TT,CGC,TDI
                                            OFA good MF1661G25F OFEL CERF-Coburngore Courtney
I hereby certify that this pedigree is true and correct to the best of my knowledge and belief
Signed By: __________________________________________________  Signature: __________________________________________________
Date: ______________________________  Address: ___________________________________________________________________________

__________________
Lorie
Sandragon Mastiffs
Where Mastiffs and Dragons play!
http://sandragonmastiff.com


This post may not be forwarded, copied, transmitted, or reprinted without the permission of the sender!
smokerise

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Posts: 140
Reply with quote  #13 
My past boy Hillsides Sir Gulliver (Fawn) ws05924803
Sire Colonel Jackson wr01357103
Dam Missy IV  wr015270003

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webb
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Posts: 4,215
Reply with quote  #14 
My past boy Hillsides Sir Gulliver (Fawn) ws05924803
Sire Colonel Jackson wr01357103
Dam Missy IV  wr015270003

Sex: Male   Date Whelped: 9/1/2003   Color: fawn
Notes: STUD8/05
                                                              -Ch. Old School Sergeant Major
                                          -Old School Edgar Man
                                          |                       -Ch. Old School Lady Portia
                      -Redemption's Way Will-O-Resa
                      |                           |                       -Lionsire Hayden's Buddy
                      |                           -Amy's Lady Lucy
                      |                                               -Lady Sadie Of Baltimore
  -Tims Silver Max A Million
  |                       |                                               -Ch. Banyon's Cosby
  |                       |                           -Northwinds KB Jake Ellwood
  |                       |                           |                       -Glass Onion's Star Of Juno
  |                       -Nia Avar Romulus
  |                                           |                       -Oak Lair Bodacious Beaufort
  |                                           -Ricas Miss Biggy
  |                                                               -Sheba Tristan Of Troy
-Colonel Jackson
| |                                                               -Am.Can.Ch. Tejas Ironman Tyson
| |                                           -Sir Mangus Xavier Grant
| |                                           |                       -Tejas Ali's Clancy
| |                       -Sir Caesar Cerberus Grant
| |                       |                           |                       -Arciniega's Rowdy Red Rooster
| |                       |                           -Millie Of Burnt Mill Road
| |                       |                             OFA good MF1751G27F-Big Muggs Sunflower Tigger
| -Old School Queen Isabelle
|                       |                                               -Tyran Of Sir Grizzleys
|                       |                           -Titan Knoll's Bulldozer
|                       |                           |                       -Noble's Little Miss Peaches
|                       -Princess Enga Corona
|                                           |                       -CC Menagerie Bull Again
|                                           -Forestview's Holly
|                                                               -OK JJ's Crusading Mahriah
-

|                                                               -Ch. Carter's Grove's Jake ,CGC,TDI
|                                           -Willow Run Brooklyn
|                                           |                       -Willow Run Sarah
|                       -Mighty Max Attack
|                       |                           |                       -Foxfire's Gentle Ben
|                       |                           -Joey's Lucky Star
|                       |                                               -Foxfire's Tequila Sunrise
| -Funny Farm's Giant Gunther
| |                       |                                               -Bo-Bear Jr
| |                       |                           -Cody's Boy Sampson
| |                       |                           |                       -Maureen's Golden Fawn Renee
| |                       -Sheeba Sampson Kelly
| |                                           |                       -Greiner Hall Renegade
| |                                           -Jasmine Rose Kelly
| |                                                               -Wenmars Southern Belle Foxfire
-Missy Iv
  |                                                               -Tyran Of Sir Grizzleys
  |                                           -Titan Knoll's Bulldozer
  |                                           |                       -Noble's Little Miss Peaches
  |                       -Zeus Rumble Dozer
  |                       |                           |                       -Oak Lair Bodacious Beaufort
  |                       |                           -Forestview's Jadot
  |                       |                             OFA excellent MF1541E26F-Lugar's Princess Kelma
  -Funny Farm's Cleo
                      |                                               -Task Force Of Windridge
                      |                           -Barkley's Damien Of Windsor
                      |                           |                       -Greco's Duchess Of Windridge
                      -Gladerun's Embers Lace
                                          |                       -Big Bobs Brutus
                                          -Lucia
                                                              -Dar-Lins Sabel
I hereby certify that this pedigree is true and correct to the best of my knowledge and belief
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smokerise

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Reply with quote  #15 

Thank you Lorie


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Reply with quote  #16 
Tigris Stella Bella, daughter of a positive male, and daughter also of a carrier (her litter brother Lumpy was positive, but never bred, his being positive proved that their mother was a carrier). 
 
Stella produced two positive sons, one in each of her two litters, Tigris Tyger Tyger (OFA Excellent but neutered young), and Tigris Black Forest Cake (who tested negative before being sold). 
 
Stella's other sons were tested several times and never tested positive.  Stella, being the daughter of a carrier and a positive, had a 50/50 chance of being one of the extremely rare positive females, but tested negative multiple times and was clear by necropsy after her death.  In other words, she did not HAVE Cystinuria, she was "only" a carrier.
--------------------------------------------------------------
 
laurie (Mother Mastiff)
 
Registered Name: Tigris Stella Bella
Reg. #: WP895807/02   Sex: Female   Date Whelped: 2/15/1997   Color: fawn brindle
Notes: OFAg MF3771G31F-T,OFEL,OFPg,OFEP,MFCA,CERF1&12,STUD11/99
                                                              -Belbeck Plantation Boss
                                          -Eng.Ch. Trevabyn Black Ice
                                          |                       -Coopell Malanese
                      -Farnaby Touch Of Class At Trev
                      |                           |                       -Eng.Ch. Parcwood W. Bear Esq of Lesdon
                      |                           -Farnaby Special Features
                      |                             OFA excellent     -Dark Devina Of Farnaby
  -Farnaby Fearful Symmetry ,CGC
  | OFA good MF1362F27G OFEL MFPA14 CERF|                       -Eng.Ch. Glynpedr Dom Perignon
  | vWD Clear Thyroid Normal |                   -Eng.Ch. Damaria Count Magnum
  |                       |                           |                       -Nandina Shady Lady Of Damaria
  |                       -Eng.Ch. Farnaby Fraze And Fable
  |                                           |                       -Eng.Ch. Parcwood W. Bear Esq of Lesdon
  |                                           -Farnaby Special Features
  |                                             OFA excellent     -Dark Devina Of Farnaby
-Am.UKC.Ch. Gold Coasts Woodrow F Call ,CGC,TDI
| |OFA good MF2211G24M OFEL CERF                               -Willowledge J Johnson
| |Thyroid Normal                           -Ch. Royalcourt Jonah
| |                                           |                       -Ch. Sanobar Saxon Queen
| |                       -Ch. Willowledge Recon Sniper ,CD
| |                       |                           |                       -Ch. Bournewood Edwin
| |                       |                           -Royalcourt Jesabelle
| |                       |                                               -Sanobar Lady Ashton
| -Gold Coasts Emelia
|   OFA good MF871G26F OFEL MF42-T CERF|                       -Ch. Ram's Gate Job
|   vWD Clear Thyroid Normal |                   -Ch. Gulph Mills Resounder
|                       |                           |                       -Ch. Dame Sybil Of Greenbranch
|                       -Walnut Hill Resolve ,TT
|                         OFA fair MF438F CERF|                       -Hippocrates Mister Barry HM
|                         vWD Clear Thyroid Normal -Winterwood Raconteur
|                                                               -Ch. Greenbranch Lady Chelsea
-

|                                                               -Craig Goch Cadlyn
|                                           -Belbeck Plantation Boss
|                                           |                       -Monterosa Lovely Lady
|                       -Eng.Ch. Trevabyn Black Ice
|                       |                           |                       -Merripit's Kermit
|                       |                           -Coopell Malanese
|                       |                                               -Coopell Merry Shadow
| -Farnaby Touch Of Class At Trev
| |                       |                                               -Eng.Ch. Overnoons Mr. Micawber of Buck
| |                       |                           -Eng.Ch. Parcwood W. Bear Esq of Lesdon
| |                       |                           |                       -Eng.Ch. Farnaby Rainy Patch
| |                       -Farnaby Special Features
| |                         OFA excellent           |                       -Farnaby Flattering Figure
| |                                           -Dark Devina Of Farnaby
| |                                                               -Aunty Bobbetty Of Bulliff
-Farnaby Well Turned Fraze
  |OFA good MF1853G34F OFEL CERF                               -Farnaby Lord Alexanderson
  |vWD Clear Thyroid Normal                   -Lesdon Lord FortescueOfFarnaby
  |                                           |                       -Lesdon Lady Diana
  |                       -Farnaby Fair'n Square
  |                       |                           |                       -Nantymynydd Nefin
  |                       |                           -Wyaston Mary Rose
  |                       |                                               -Nantymynydd Daphne
  -Farnaby Magic Moment
                      |                                               -Eng.Ch. Glynpedr Dom Perignon
                      |                           -Eng.Ch. Damaria Count Magnum
                      |                           |                       -Nandina Shady Lady Of Damaria
                      -Farnaby Fortune Personified
                                          |                       -Eng.Ch. Parcwood W. Bear Esq of Lesdon
                                          -Farnaby Special Features
                                            OFA excellent     -Dark Devina Of Farnaby
I hereby certify that this pedigree is true and correct to the best of my knowledge and belief
Signed By: __________________________________________________  Signature: __________________________________________________
Date: ______________________________  Address: ___________________________________________________________________________

__________________
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Tracy

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Reply with quote  #17 
Ok, I was researching some autosomal recessive theories for a friend who has an amino acid issue.  This information is collected about human cystinuria, and I think alot of points here are very very valid, esp the different types of cystinuria, and transmission, as well as treament. Forgive the cut and paste, I normally like to expalin things in my own words, but these double shifts are making me very tired!!

How frequent is cystinuria?

Cystinuria is one of the more common genetic disorders. Its overall prevalence is about 1 in 7,000 in the population.

Cystinuria is the most common defect known in the transport of an amino acid.

What is a transport defect?

Within the body, many molecules are able to pass across the membranes that surround cells. These molecules can accomplish this feat due to specific transport systems. These systems include special receptors on the membrane of the cell and special carrier proteins. The receptor recognizes the molecule and receives it on the cell membrane. Then the molecule hitches a ride through the cell membrane on the back of a carrier protein.

With such remarkable specificity, it is little wonder that sometimes there are defects in transport systems. Several dozen different diseases are now known to be due to transport defects.

What causes cystinuria?

Cystinuria is caused by the defective transport of cystine and several other amino acids through the cells of the kidney and the intestinal tract.

What happens with cystine in the urine?

Although cystine is not the only overly excreted amino acid in cystinuria, it is the least soluble of all naturally occurring amino acids. Cystine precipitates, or crystallizes out of urine and forms stones (calculi) in the kidney, ureter, bladder, or anywhere in the urinary tract.

How is cystinuria treated?

High fluid intake: The foremost aim of treatment is to prevent the formation of cystine stones. This goal is attained mainly by increasing the volume of urine. The reason for the increased urine volume is simple. By increasing the volume of urine, the concentration of cystine in the urine is reduced which prevents cystine from precipitating from the urine and forming stones.

Cystine stones in many patients can be dissolved and new ones prevented by a high fluid intake. What high fluid intake means in this context is an absolute minimum of 4 liters (roughly 4 quarts) per day. An intake of 5 to 7 liters a day is ideal. The fluids must be spaced out, including through the night. It has been said that people with cystinuria must realize that "for them, water is a necessary drug."

Alkalizing the urine: Another strategy that has been attempted to treat cystinuria is alkalization of the urine. The rationale is that in an alkaline (nonacidic) liquid, cystine tends to stay in solution and there it does no harm. To make the urine alkaline, sodium bicarbonate (and similar substances) have been used. This treatment is not without hazard because it can, while preventing cystine stones, lead to the formation of other types of kidney stones.

Penicillamine: For people with cystinuria in whom a consistent, conscientious high fluid intake does not succeed in halting the formation of stones, another option available is regular treatment with a drug called penicillamine. Penicillamine (Cuprimine, Depen) acts to form a complex with cystine that is 50 times more soluble than cystine itself

What are the laboratory findings in cystinuria?

The key laboratory finding is a large amount of cystine in the urine. There are also increased urinary levels of 3 other amino acids with a similar structure -- lysine, arginine, and ornithine. The membrane transport for cystine is unique to cystine but serves to transport all 4 so-called dibasic amino acids -- lysine, arginine, orthnithine and, of course, cystine.

This excess of amino acids in the urine constitutes aminoaciduria. Some persons (heterozygotes) carrying just one gene for cystinuria have aminoaciduria, although milder. There are actually 3 types of cystinuria. Carriers of 2 of these types of cystinuria (types II and III) show abnormal amounts of cystine in their urine.

How is cystinuria inherited?

The genetics of cystinuria are complicated.

There are, as mentioned, 3 types of cystinuria. They are termed cystinuria type I (abbreviated CSNU1), cystinuria type II (CSNU3), and cystinuria type III (CSNU3). Each type of cystinuria can be inherited as an autosomal recessive trait. For example, in a family each parent may have one CSNU1 gene (and a normal gene paired with it) while their boy or girl may have the misfortune of receiving the CSNU1 gene from both of them, thereby acquiring cystinuria.

Cystinuria type I (CSNU1) is caused by a mutation (a change) in a gene (the SLC3A1 amino acid transporter gene) which is situated on chromosome 2p16.

Cystinuria type 2 (CSNU2) is, quite remarkably, also caused by a gene in 2p16.3. Studies of families with both cystinuria I and cystinuria II have shown that the genes for CSNU1 and 2 are at exactly the same spot in chromosome 2p16.3 and in fact both involve the same gene (the SLC3A1 amino acid transporter gene).

CSNU1 and 2 are therefore said to be allelic. The fact that CSNU1 and 2 are allelic means that genetic compounds can form, producing three clinical types -- persons with not just CSNU1/CSNU1 and CSNU2/CSNU2 but also the compound type CSNU1/CSNU2.

Cystinuria III (CSNU3) is due to a mutation at a separate location, namely at chromosome 19q13.1.

So, when I very quickly read through this, there is a possiblity that we are looking at, possibly based on the human model, different types of cystinuria, which have different loci on the genes for transmission. This would certianly explain why we dont see the direct autosomal transmission that we think it should follow.

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slobber2

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Reply with quote  #18 
Hi Tracy :>)
Good post :>) I don't know anything on Genetics :>)

But I think , when they find this gene ,i don't think it will be Xlinked .
But what do i know :>)  I think you will need it on both side of the pedigree .

Or two in the same pedigree ?? But the experts feel its Xlinked ??

So I cant argue with it :>) But it seems your article here is saying that also ??

I think we all need a thread or page up . On the right way to test for this and make sure we do testing 2 to 4 hrs after eating , and sending in frozen urine .


Seems some of us still don't get it :>) Also once a year it should be redone .

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Reply with quote  #19 

"Urolithiasis in Dogs

Astrid Hoppe,DVM, PhD

 

CYSTINE UROLITHIASIS

 

Etiopathogenesis and biological behavior

Cystinuria is an inborn metabolic disease characterized by excessive urinary excretion of cystine and the dibasic amino acids lysine, arginine, and ornithine. In normal dogs, circulating cystine is freely filtered at the glomerulus, and most of it is actively reabsorbed in the proximal tubules. Cystinuric dogs reabsorb a much smaller proportion of the amino acid from the glomerular filtrate, and some may even have net cystine excretion.20 The solubility of cystine in urine is pH dependent, and it is relatively insoluble in acid urine but becomes more

soluble in alkaline urine. The exact mechanism of cystine urolith formation is unknown.Although increased urinary cystine excretion is found in both males and females, uroliths are most commonly found in males.

 

In a Swedish study, the urinary excretion of 20 amino acids was investigated in 24 stone-forming cystinuric dogs and 15 normal dogs.21 Compared with the normal dogs, most cystinuric dogs showed significantly increased excretion of cystine, lysine, arginine, ornithine cystathionine, glutamic acid, threonine, and glutamine. A most significant finding was the great variation in urinary cystine excretion. Seven of 24 cystinuric dogs showed normal cystine excretion at the time. This suggests that factors other than excretion of cystine have to be considered as causes of the formation of cystine uroliths. In a recent study, the clinical features and metabolic renal abnormalities

in 11 cystinuric Newfoundlands were described.20 In this study, however, all affected dogs persistently excreted

excessive amounts of cystine compared with other related Newfoundlands without cystinuria. In the same study, the mode of inheritance of cystinuria was evaluated.Although clinical signs of urinary obstruction were observed only in males, cystinuric male and female offspring were produced from noncystinuric parents, consistent with an autosomal recessive mode of inheritance.

 

Obligate heterozygotes did not have clinical signs and had normal urinary cystine content and renal amino acid reabsorption. Surprisingly, cystine uroliths are often not recognized until maturity,with the average age of detection being approximately 3 to 5 years. Because cystinuria is an inherited defect, uroliths commonly recur within 6 to 12 months (in some dogs, within 4 to 8 weeks) unless prophylactic therapy is initiated. Apart from the uroliths, cystinuric dogs have no other defects and normal renal function, and the disease would have remained a physiological curiosity if cystine had not been the least soluble naturally occurring amino acid, and thus potentially

leading to the formation of cystine uroliths.

 

Characteristics, prevalence and diagnosis

Cystine uroliths (Figure 4) account for 3.5% to 27% of the canine uroliths, probably depending on the breed of dogs

encountered in specific surveys. Many breeds of dogs have been reported to develop cystine uroliths. In Sweden and Germany, cystine urolithiasis is particularly a problem in the dachshund, and it accounts for approximately 4% and 18.8% , respectively, of uroliths analyzed from the dog populations in those countries.22

 

Although, cystinuria is found in both males and females, cystine uroliths have been reported most commonly

in male dogs.22 The presence of flat hexagonal cystine crystals provides strong support for a diagnosis of cystinuria. However, not all dogs with cystine uroliths have concomitant cystine crystalluria. If a sufficient quantity of cystine is present in urine (>10 mmol/mol creatinine), the cyanide-nitroprusside test result for cystine will be positive.23 False-positive reactions due to medication with sulfur-containing drugs have been reported, but

the author¢s experience is that this test is a reliable and simple diagnostic procedure. For quantitative measurement of urinary cystine excretion, 24 hour urine should be collected and quantified

by, for instance, ion exchange chromatography.21

 

Treatment and prevention

Current recommendations for dissolution and prevention of cystine uroliths encompass reducing the urine concentration of cystine and increasing the solubility of cystine in urine.Therapeutic approaches may be divided into four categories: reduction and change of dietary protein intake, aimed at reducing cystine production and excretion increase of diuresis increase of cystine solubility conversion of cystine to a more soluble compound.

 

Dietary modification

Attempts have been made to design diets low in methionine to decrease the excretion of cystine in humans, mostly with disappointing results. At the Swedish University of Agricultural Sciences, we have used a protein-restricted diet designed for dissolution of canine struvite uroliths in two dogs with cystine uroliths; the uroliths did not dissolve.23 Studies in humans conclude that, despite a defective proximal tubular reabsorption of cystine in cystinuria, the reabsorption can be increased by dietary sodium restriction.3 Our own preliminary studies indicate

that the effect of dietary sodium restriction in dogs might be the same as for humans.

 

Increase of diuresis

Increase of water intake provides a progressive reduction in urinary cystine concentration and reduces the likelihood of precipitation.

 

Alteration of solubility

Cystine solubility can be enhanced by inducing an alkaline pH, but the solubility does not increase significantly until the pH is above 7.5.Administration of bicarbonate and citrate, for example, has been advocated for improving solubility, but the author¢s clinical experience, as well as that of others, suggests that not much practical benefit is achieved.23

 

Conversion to a more soluble compound

Chemical modification of the cystine molecule into a more soluble form with D-penicillamine or 2-mercaptopropionylglycine (2-MPG) has been suggested. This would be expected to decrease cystine excretion into the urine and to diminish the likelihood of urolith formation (Figure 5). Although D-penicillamine is effective in preventing the formation, and sometimes the dissolution, of cystine uroliths, there are frequent complications

that limit its use. In dogs, the most prominent side effect is vomiting. Another property of penicillamine is chelation

of metals. In a study of 11 normal beagles given D-penicillamine orally and intravenously, significantly increased excretions of calcium, copper, zinc, chromium, cobalt, iron, and magnesium were found.24

 

2-MPG is chemically related to D-penicillamine but has a higher oxidation-reduction potential and may therefore be more effective in a disulfide exchange reaction.A clinical study was performed on 25 cystinuric dogs receiving oral treatment with 2-MPG for periods of between 1 and 6 years.23 The drug was effectivein urolith dissolution when given at a dose of approximately 40 mg/kg.Thus, in 15 dogs with uroliths found in the bladder on 17 occasions, complete urolith dissolution was achieved on 9 occasions (53%). For prophylactic therapy, a dose of 30 mg/kg is

recommended. Most dogs tolerate 2-MPG well, although transient side effects, such as thrombocytopenia, may occur.23

 

http://f1.grp.yahoofs.com/v1/wI6kSHIRMMkwefdP2UqQiJ9DOuSDLo8L7SeaXMvsgxTrv6eOVQeD3CCV6TYaKogbB8YKQ-Q8vQnAAAjCGOGU/ARTICLES%20AND%20STUDIES/Hoppe.pdf

 


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Sandragon

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Reply with quote  #20 

In some threads the topic has come up that you could make a dog cystinuric by the type of food fed. This is the responses to that. Both are posted with permission:

diet and Cystinuria

Posted by: "Windfall Mastiffs" windfallmastiffs@hughes.net   mastiffs10

Wed Aug 13, 2008 7:11 pm (PDT)

Maybe this analysis will help:
Most all make insulin in our body by the pancreas (I say most as there are Juvenile diabetics who don't make insulin) and that helps to control the blood sugar in our body and move it to the cells to store for energy. Well the more we eat, the most sugar we have, the more insulin we need to control the sugar. We can also help control the sugar levels with food or meds, which is what a diabetic must do or the levels get to high.
Well we all make Cystine, it's just a matter of how the kidney's metabolize it, some have no problems (Normal), others have a problem (Cystinuric) and when they eat certain foods, the problem can be worse (form stones or just be diagnosed C+) and these are the ones who are detected easier, earlier etc...

Okay, I'm tired and hope this makes sense!
Jan

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diet and Cystinuria

I can't believe we are going over this again. But we are.

"Cystinuria" means "cystine in urine." Period. While there may be
trace.. and I mean TRACE.. levels of cystine in the urine of dogs
without this INBORN GENETIC DEFECT, when there is cystine in the
urine beyond that, the dog has cystinuria.

Of course diet will affect LEVELS OF CYSTINE IN THE URINE OF DOGS
WITH CYSTINURIA.

But it will not make a dog who does NOT have cystinuria test as
having high levels of cystine in their urine, because their kidneys
aren't abnormal and their kidneys will do what they are supposed to
do, filter it out.

In dogs with cystinuria, however, diet makes a big difference,
because feeding certain things will cause there to be more cystine
excreted and thus, leak into the urine. That's why the researchers
want the dogs to have just eaten before urine collection, to increase
the chances that the levels will be high enough to measure. But this
only applies to dogs WHO HAVE CYSTINURIA.

You can stuff your normal dog sick on high-protein foods and you
cannot make him have high levels of cystine in his urine, because,
since he doesn't have cystinuria, his body will filter it the way
it's supposed to. You can give him PURE CYSTINE and he still won't
test as having cystinuria.

If your dog has cystine in his urine -- beyond the slightest trace --
EVER, after any kind of meal or diet, then that dog has cystinuria.

As to false positives: There are a few antibiotics that will cause,
not cystine in the urine of normal dogs, but a FALSE READING on the
nitro-prusside test. The researchers at UPenn know what those drugs
are, and if your dog is positive they will, believe me, ask you about
them. It's been so long since I sent in my dogs' info I don't
remember, but they may in fact ask you on the original submission
form.

There are no known non-genetic forms of cystinuria in any species. If
you want to lie to yourself or anyone else and say your dog, or some
dog in your dog's pedigree, didn't "really" have cystinuria despite
having cystine in his urine, or that it's caused by diet or whatever,
knock yourself out.

But it will still be a lie.

Christie Keith
Caber Feidh Scottish Deerhounds
Raising our dogs holistically since 1986
- http://www.caberfeidh.com - http://www.doggedblog.com -
http://www.caninecystinuria.com -




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slobber2

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Reply with quote  #21 
Good Post Lori :>0

If that doesn't get the point across , then we are doomed as a breed

So many are using that excuse ,Please remember a Positive is a Positive .

Its Not the food ,or the drugs .
It is what it is , and until we can all accept ,this . Breeders as will as buyers .

We will never get a handle on this genetic nightmare .

All Breeder need to work together ,to find out the Cause in your lines .

Its nothing to be ashamed of , we all thought one test and we were clear .


But now we know this is not the case , So lets start working together .

That's the only way you can do it . Take your heads out of the sand !

And face it head on .  Dont breed a C+ line of dogs

Marge






smokerise

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Reply with quote  #22 
My boy is positive Springhollows Mafia Don "Neiko" WS17501211
The breeder is promised to give a full refund !!

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Reply with quote  #23 

smokerise

My boy is positive Springhollows Mafia Don "Neiko" WS17501211
The breeder is promised to give a full refund !!





 
CH Valley View's Caleb of Rydalmount Durham's Walking Tall Valley View Beau Durham Greiner Hall Zechariah
CH Durham's Nikki Of Valley View
CH Greiner Hall Winnifred Greiner Hall Zechariah
Greiner Hall Medicine Lady
Pallone Joint Venture CH Smok'N Lad's Sand River Rio CH Eastland's Zachary Of Smok'n Lad
CH Smok'n Lad Stormy Dominic
Pallone's Crowning Glory Am. Can. CH Greiner Hall Jedadiah
Arciniega's Sweet Fatima
CH Erieside Edith Anne CH Greco's Titan I Did It My Way CH Greco's Hollesley Rogue CH Falmorehall Fortescue
CH Greco's Hollesley Trist Jean
Greco's Saint Gertrude CH Greco's Hollesley Sam
Greco's Hollesley Maid
Pallone's Sweet and Sassy Hazel CH ARCINIEGA'S SWEET WILLIE ARCINIEGA'S MERANI BETO
Arciniega FWL Cleo Sahiba
Pallone's Crowning Glory Am. Can. CH Greiner Hall Jedadiah
Arciniega's Sweet Fatima

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francesp1066

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Reply with quote  #24 
Last night I received the results and my Ziggy is Positive. Today tried to reach all my puppy owners. If you have any dogs from this line please test you mastiffs. This is very important.


Dralion Sir Ziggy Stardust
Sire Greiner Hall Neo
Dam Greiner Hall Zoe
slobber2

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Reply with quote  #25 
Oh Damn Fran Im so sorry
was it at the picnic you had him tested ??

HUgs Marge
francesp1066

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Reply with quote  #26 

Yes, I was going to test him a few weeks before that but once I heard they were having a clinic I waited till then to do testing.

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Reply with quote  #27 
Thank you for posting.
I am so sorry.

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Moneletto

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Reply with quote  #28 
Batista tested Positive
francesp1066

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Reply with quote  #29 

                                                               Sire: Greiner Hall Nicholas
                                                        Sire: Greiner Hall Egan
                                                                                              Dam: Greiner Hall Tuppence
                              Sire: Greiner Hall Neo
                                          PRA DNA Clear

                                                                                                Sire: Ch. Alevdors Aragorn
                                                        Dam: Knights Grizzlys Calinete
                                                                                                Dam: Greiner Hall Knights Isa-Tai

Dralions Sir Ziggy Stardust
OFA Good, OFEL, PRA Clear, Positive for Cystinuria
                                                                                                Sire: Ch. Alevdors Aragorn
                                                       Sire: Greiner Hall Nicholas
                                                                                                 Dam Greiner Hall Isabella
                                   Dam: Greiner Hall Zoe
                                             PRA DNA Clear
                                                                                                  Sire: Greiner Hall Zechariah
                                                       Dam: Ch. Valley View Sally Bear
                                                                                                  Dam: Ch. Durham's Nikki of Valley View

francesp1066

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Reply with quote  #30 

Just thought I mention that I had Ziggy tested a second time and he came back positive again.

Moneletto

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Reply with quote  #31 

Has anyone taken there dog to UPenn personally for a blood draw and urine sample?? 

slobber2

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Reply with quote  #32 
HI :>)
Not that i know of .
But that's a good question .
Maybe if you put it too the Cystinuria list . They can answer that :>)

Marge
LindaGreesonRice

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Reply with quote  #33 

The Napotniks have been testing their dogs for Cystinuria (Yeah Stephen,

cudos to you for testing - I wish more people would) and has asked me to post
 
the results. This is very good news for a lot of people..
 
"As for any speculation that Nic was the link, he is, unfortunately, gone from us. 
 All we can say is that Neo is a Nic grandson, Brutus is a Nic great-grandson,
and Grappa is a Nic grandson and great-great grandson, and all are negative. "
 
Neo, Brutus and Grappa have all tested negative.
 

 
Attached Files
pdf Brutus_Napotnik.pdf (20.01 KB, 209 views)
pdf Grappa_Napotnik.pdf (20.11 KB, 129 views)
pdf Neo_Napotnik.pdf (20.01 KB, 159 views)


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Linda Greeson Rice
AKC Breeder of Merit

The Mastiff Sweet Spot
http://www.bluequaker.com/Mastiffs.htm



We do not breed often, but we do our best to breed top quality mastiffs
with excellent pedigrees to back them up. All breedings are carefully planned to produce
the very best mastiffs, sound in both body and mind, beautiful and strong,
representing the true mastiff standard.

We fully test our dogs. We believe that a person that "just wants a pet" has a right
to own a beautiful, well bred dog that is sound and healthy
every bit as much as someone wanting a "show dog".

slobber2

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Reply with quote  #34 
Thats wonderfull news :>)
A big congrads to Stephen and Leah :>)
They are fine people
Marg e
lamars

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Reply with quote  #35 
I am the breeder of this dog he tested Positive they changed his diet and he never formed stones. He is now 8 years old.
Pedigree for Lamars Woofus Maximus
Mastiff Fawn Black Mask

Sire
Ch.LaPaw's Drake of Diamondhead
Sire
Int.Am.Ch. Groppetti Thorg of Windzor
Sire
Ch.Semper Fi Groppetti Gargoyle
Sire
Ch.Deer Run Semper Fi Thor
Dam
Dee Run Semper Fi Kerra ,CD
Dam
Groppetti Tug Boat Annie
Sire
Deer Run No more Mr Nice Guy
Dam
Groppetti Carmel
Dam
Lady Roweena of Flintcreek
Sire
Greco's Falmore Bonner
Sire
Ch.Falmorhall Fortescue
Dam
Ch.Greco's Sacha Sarele
Dam
Rachel Renee Hogan
Sire
Ch.Greco's Hollesley Rogue
Dam
Greco's Saint Renne Spot
Dam
Lamars Mahvelous Magdelenda
Sire
Ch.Lamars JJ Wilder C.G.C.
Sire
Lamars Brandon Le'Moose
Sire
Ch.Southports Black Orpheus
Dam
Deer Run Brandy Ann
Dam
Knightsen's Muir Oaks Sophie
Sire
Lamars Brandon Le' Moose
Dam
Knightsen's Muir Oaks Sophie
Dam
Paxrivers Lamars Evelyn
Sire
Ch.Paxrivers Dozer by Sidetrack
Sire
Ch.Deer Run River Bull
Dam
Ch.Sidetrack Farm Beatrice
Dam
Belairs Bess of Paxriver
Sire
Ch.Paxriver Nemisis
Dam
Ch.Beautiful Babe of Belair


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LAMARS Mastiffs
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lamars

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Reply with quote  #36 
I am the co-owner and breeder of this dog


Pedigree for Ch.Lamars Blues Clues
Mastiff Fawn Black Mask

Sire
Ch.LaPaw's Drake of Diamondhead
Sire
Int.Am.Ch. Groppetti Thorg of Windzor
Sire
Ch.Semper Fi Groppetti Gargoyle
Sire
Ch.Deer Run Semper Fi Thor
Dam
Dee Run Semper Fi Kerra ,CD
Dam
Groppetti Tug Boat Annie
Sire
Deer Run No more Mr Nice Guy
Dam
Groppetti Carmel
Dam
Lady Roweena of Flintcreek
Sire
Greco's Falmore Bonner
Sire
Ch.Falmorhall Fortescue
Dam
Ch.Greco's Sacha Sarele
Dam
Rachel Renee Hogan
Sire
Ch.Greco's Hollesley Rogue
Dam
Greco's Saint Renne Spot
Dam
Lamars Pop The Cork
Sire
Lamars Gardenator
Sire
Ch.Paxrivers Dozer by Sidetrack
Sire
Ch.Deer Run River Bull
Dam
Ch.Sidetrack Farm Beatrice
Dam
Ch.Lamars Sassy Sandy Savy
Sire
Lamars Brandon Le' Moose
Dam
Knightsen's Muir Oaks Sophie
Dam
Lamars Sunny Delight
Sire
Ch.Lamars JJ Wilder C.G.C.
Sire
Lamars Brandon Le' Moose
Dam
Knightsens Muir Oaks Sophie
Dam
Ch.MGM Greta Garbo
Sire
Ch.Justamere Mbojo of Lion Kop
Dam
Ch.RoyalOak MGM Tamara By TJ


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EileenDurante

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Reply with quote  #37 

 

 


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Reply with quote  #38 
Pedigree for Finney's Sir Noble Chuwee ( Cystinuria Positive )
mastiff

Sire
Lionhearted Noble Warrior
Sire
CH Lionhearted Maximum Power
Sire
Lionhearted Medieval Man
Sire
CH Double D Cameo's Mario
Dam
Lionhearted Double D Mariah
Dam
Grizzly's Total Eclipse
Sire
Avalons Tuscon Warrior
Dam
Lionhearted Blackberry's Gypsy
Dam
Lionhearted Lana Of Roswal
Sire
Lionhearted King Of Midnight
Sire
Avalons Tuscon Warrior
Dam
Lionhearted Blackberry's Gypsy
Dam
Kingsgate Dakota Blackfoot
Sire
Greiner Hall Sherman Tank
Dam
Von Roth's Spy's Good Girl
Dam
Miller's Graceful Nightstalker
Sire
Lesas Duke The Mighty Man
Sire
RI's Prince Sampson
Sire
Tuckasee's Deejay Sampson
Dam
Deejay's Cleopatra
Dam
RI's Princess Brandy
Sire
Hemmingway Beauregard
Dam
Princess Sassy Sable
Dam
Lesas Queen Lady Tabitha
Sire
Cabin Creeks Ramblin Zues
Sire
Grubby's Bud Light
Dam
Griffin's Lady Abigail
Dam
Almighty Athena Of The Fields
Sire
Cabin Crekks Almighty Zeek
Dam
Cabin Creeks Joly Mable

This pedigree page was built for free at SitStay.com Get your Dog Supplies at SitStay.com


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MommaMorrison

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Reply with quote  #39 
Hi Eileen!  I'm new to this forum, and also new Mastiff owners as well!  Our pup is almost 6 months old, and sweet as can be.

I was just googling our pup's dam and sire, and came across this thread.  I'm not sure what this disease is that is being discussed, but his dam and sire are Wassam's Mighty Max and Mella-Fella's Ms Sissy Britches.  Sissy Britches' dam and sire are Lionhearted Noble Warrior and Miller's Graceful Nightstalker. 

Could you break this down for me and explain what this may mean for our pup?  Thank-you.
Meg

slobber2

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Reply with quote  #40 
Hi Meg :>)
I just happened to see your post :>)
I would say your Boy shoul dbe tested ,for Cystinuria every year
If your thinking of breeing Him . I would not breed Him ,untill we find the DNA Markers ,for this Genetic Illness .

You can find out about Cystinuria On this page or on the MCOA webbsite :>)

Marge
kristiE

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Reply with quote  #41 
Meg,

Welcome to the forum.  Sorry you found your self in a scary thread.  In a nut shell, your puppy's mother has a brother that has tested positive for cystinuria.  It is unknown the exact transmission of the disease, but cystinuria is presumed to be genetic and possibly sex linked.  We don't really know yet.  Much research is being done, as this disease causes stones to form in the urinary system of male dogs that is very painful and can be expensive and difficult to treat effectively.  Please research the disease and be cautious of your boy's toilet habits.  Chances are since your boy is young you won't see anything until closer to adulthood if he is affected, however, vigilance is the key.  An educated owner is the best policy.  This forum is a great resource for information.  All the best, and again welcome.

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Magnum

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Reply with quote  #42 
A helpful link for "stones":  http://homeocare.blogspot.com/2006/06/renal-stone.html
Check it out and decide for yourself.
JJ

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Reply with quote  #43 
Great I see a lot of Greco on here.  My Magnus is almost all Greco. 

JJ


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LindaGreesonRice

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Reply with quote  #44 

JJ - I do not think there is any bloodline that is immune to this disease - all we can do is test and not to pass it on to future generations.


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AKC Breeder of Merit

The Mastiff Sweet Spot
http://www.bluequaker.com/Mastiffs.htm



We do not breed often, but we do our best to breed top quality mastiffs
with excellent pedigrees to back them up. All breedings are carefully planned to produce
the very best mastiffs, sound in both body and mind, beautiful and strong,
representing the true mastiff standard.

We fully test our dogs. We believe that a person that "just wants a pet" has a right
to own a beautiful, well bred dog that is sound and healthy
every bit as much as someone wanting a "show dog".
Gunter

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Reply with quote  #45 

Do all these results come from UPenn?  Is that the only place that does it?  Can one's vet do it in their office?  Sorry if this is a dumb question but I have been absent from the scene for some time and am just learning about cystinuria.

annagmay

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Reply with quote  #46 
UPenn is the recommended lab or choice because they are doing research for the disease and they need the data to help fully understand it in our breed.  They are studying the genes (DNA) and the COLA levels of the urine...

There are human labs that do the testing, especially at children's hospitals, universities and private labs, but it is not a commonly ran test at most labs and not readily available for animals.

UPenn is the only lab that does the nitroprusside urine tests on animals that I am aware of or that I would recommend anyone to use.  The NP Urine test can detect elevated cystine in the urine even in the absence of cystine crystals or stones.

Every veterinarian can spin down urine to look for crystals which may or may not be present in the dogs urine even if they are cystinuric.  The cystine crystals should be easy to identify due to their unique shape, but many vets do not properly diagnose it. 

When the dogs are diagnosed with cystine crystals in their urine or cystine stones in their bladder...  There are a few labs that offer stone analysis to positively identify what type of stones the dog has, but the University of Minnesota's Stone Lab is the preferred choice.  The University of Minnesota offers FREE stone analysis at their facility and they work with various researchers, veterinarians, and universities...  If a dog (or any animal) has any type of urinary crystals or stones, PLEASE send them to the University of Minnesota Stone Lab for analysis.

Today we know that we should be testing intact "adult" male dogs.  Testing younger dogs is being proactive in case they have elevated cystine in their urine at a young age, but most Mastiff boys are not going to test positive until probably around 24 months of age or older.  Several dogs have been tested at 1 yr to 1 1/2 year normal and they test positive at 24 to 30+ months...  The recommendation is to test the boys annually or before each breeding through the University of Pennsylvania.

Anna
ethertonhaverly

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Reply with quote  #47 

Am I correct in that the disease is least likely to appear in females?

Magnum

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Reply with quote  #48 
Quote:
Originally Posted by ethertonhaverly

Am I correct in that the disease is least likely to appear in females?


Essentially, yes.

Though the exact mode of transmission is not as yet been determined it seems as though the males are the "afflicted" ones.
ethertonhaverly

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Reply with quote  #49 

Magnum- so because we are looking for a pet, not show/breeding...if a female is a carrier should we be concerned? Just trying to be eduacated in the matter.

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Reply with quote  #50 
Quote:
Originally Posted by ethertonhaverly

Magnum- so because we are looking for a pet, not show/breeding...if a female is a carrier should we be concerned? Just trying to be eduacated in the matter.


For your own pet, IMHO, no.

If you are asking on a more eclectic level, as in promulgation of a problem and enabling someone who knowingly bred said litter and then potentially profits from this, perhaps it is problematic . . .
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